The Shah Group uses viruses and engineering principles to perturb and control biological networks. We are interested in three major questions:
- How do viruses hijack cellular networks turn cells into viral factories?
- How does viral disruption of cellular networks cause disease?
- Can we control these cellular networks for biomedical and biotechnology applications?
We use complementary techniques of global proteomics, genetics, high-throughput sequencing, microscopy and synthetic biology to tackle these questions. Our efforts will uncover new biology, lead to the development scalable screening platforms, and new tools and potential therapies.